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New Blood Test Could Provide More Precise Prostate Cancer Risk Assessment

NEW YORK, NY--(Marketwired - Mar 25, 2014) - A new prostate cancer blood test, currently in testing, may
 soon facilitate more precise prostate cancer diagnosis. Early findings indicate that gene mutations, similar to those identified in breast cancer screenings, may help experts more accurately predict a man's risk of aggressive prostate cancer. More widespread availability of the prostate cancer genetic screener is anticipated within the next year.

Prostate cancer is currently diagnosed through a combination of assessments, including routine prostate-
specific antigen (PSA) blood tests, a digital rectal exam (DRE), and a prostate biopsy. "While the PSA test is very valuable, it is not a prostate cancer specific test," explains David B. Samadi, MD, Chairman of Urology and Chief of Robotic Surgery at Lenox Hill Hospital. "Elevated PSA levels can indicate an enlarged prostate, prostate inflammation, or prostate cancer."

In vetting this new diagnostic tool, researchers are
exploring how second-generation sequencing technology can be used to determine the frequency of mutations in 22 tumor suppressor genes and how those mutations correlate to prostate cancer risk and disease aggression. In an initial study, 191 men with strong family histories of prostate cancer were tested for the 22 tumor suppressor genes. Among the study participants, researchers identified 14 loss-of-function (LoF) mutations commonly associated with aggressive or advanced-stage prostate cancers.

Understanding how the frequency of mutations may predispose men to familial and/or aggressive prostate cancer may change the course of care. "In-depth assessment of an individual's genetic predispositions opens the door to tailored prostate cancer screening; individualized attention is always our goal," said Dr. Samadi.

Prostate cancer genetic testing could mean a more customized approach to prostate cancer prevention, screening, and treatment. The combination of known risk factors and genetic predispositions would allow men to make adjustments in diet and lifestyle, and give medical professionals the opportunity to screen in a very targeted way.

"My hope is that in the near future men who are diagnosed with prostate cancer can leverage genetic knowledge to make treatment decisions based on their individual disease aggression and recurrence risk," stated Dr. Samadi. "For example, if a man carries these genetic mutations we may preemptively start radiation after robotic prostate surgery to further reduce the risk of recurrence."

The study findings were published on February 20, 2014, in the British Journal of Cancer, 

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* The benefits of robotic surgery cannot be guaranteed as surgery is both patient and procedure specific. Previous surgical results do not guarantee future outcomes.

Stephen, B

I want to take a moment to thank you and your wonderful medical team for my successful surgery. In October of 2011 I was diagnosed with prostate cancer, and I immediately did a lot of research into my plan for treatment...

Bill O., New York, USA

“NO ONE HAS TO DIE OF PROSTATE CANCER EVER AGAIN! The hospital and Dr. David Samadi are the BEST! They saved my life with no pain, no strain. They can do the same for you!

G. P., New York, USA

"I am truly grateful to Dr. Samadi. The path he took from the Middle East to America enabled me and many others to have the opportunity to be helped by this caring man. A man I now call a friend. I will take a PSA in the end of May. I am confident the result will be OK just as Dr. Samadi promised."

Ezra R., Israel

שמי עזרא אני בן 51 והתגלה אצלי סרטן ערמונית לפני שמונה חודשים.מהרגע שהסרטן התגלה הבנתי שיש הרבה שיטות טיפול והיה מאד קשה להחליט על צורת הטיפול והנושא הצריך לעשות שיעורי בית יסודיים.