Prostate Biopsy: What to Expect Before, During, and After

What Is a Prostate Biopsy?

A prostate biopsy is a procedure where small tissue samples are taken from the prostate gland to check for the presence of cancer cells. It’s typically recommended when:

• PSA levels are higher than expected for your age
  
  
• Your PSA has increased rapidly over time (PSA velocity)
  
  
• A digital rectal exam (DRE) reveals a lump or abnormality
  
  
• Imaging tests, such as a prostate MRI, show suspicious areas
  
  

The collected tissue is sent to a lab where a pathologist checks for cancerous or precancerous cells.

Before the Biopsy: How to Prepare

Dr. Samadi provides detailed pre-procedure instructions to ensure the biopsy is safe and effective. Preparation may include:

1. Antibiotics

You’ll be prescribed antibiotics to lower the risk of infection. Be sure to take them exactly as instructed before and after the procedure.

2. Medications

Let your doctor know if you take blood thinners, aspirin, or other medications that affect bleeding. You may need to pause them temporarily.

3. Bowel Preparation

A mild enema may be recommended to empty the rectum before the biopsy if a transrectal approach is used.

4. Diet

Most patients can eat a light meal beforehand, but follow the specific instructions provided by Dr. Samadi’s team.

During the Biopsy: What Happens in the Exam Room

There are two main types of prostate biopsy techniques:

1. Transrectal Ultrasound-Guided Biopsy (TRUS)

This is the most common method. A small ultrasound probe is inserted into the rectum to guide the needle into the prostate. Multiple samples are taken in under 10 minutes.

2. Transperineal Biopsy

In this newer technique, samples are taken through the skin between the scrotum and rectum (the perineum). This method has a lower risk of infection and is especially useful for targeting specific areas seen on MRI.

Dr. Samadi uses precision-guided technology to ensure accuracy while minimizing discomfort.

Does a Prostate Biopsy Hurt?

Most patients experience minimal discomfort. A local anesthetic is used to numb the area, and the procedure is typically described as brief and tolerable. Some men report a slight pressure or a snapping sensation as the samples are taken.

After the Biopsy: What to Expect During Recovery

Recovery from a prostate biopsy is usually quick, but some temporary side effects are common:

• Blood in urine or semen (usually resolves within a few days to weeks)
  
  
• Mild soreness in the biopsy area
  
  
• Light rectal bleeding
  
  
• Temporary difficulty urinating (rare)
  
  

Dr. Samadi provides all patients with clear aftercare instructions, including when to resume normal activities and what symptoms to watch for.

When Will You Get Your Results?

Biopsy results are usually available within 7–10 days. Your results may show:

• Benign (non-cancerous) tissue
  
  
• Prostatic intraepithelial neoplasia (PIN) – possibly precancerous
  
  
• Prostate cancer, graded using the Gleason Score
  
  

If cancer is detected, Dr. Samadi will discuss your treatment options in detail, which may include active surveillance, surgery, or other therapies based on the cancer’s stage and aggressiveness.

How Dr. David Samadi Supports You Every Step of the Way

Dr. Samadi’s approach to prostate cancer care combines world-class clinical expertise with personalized, compassionate care. If a biopsy is recommended, you can trust that you’ll be guided through each step with clarity, support, and precision.

Whether the biopsy confirms cancer or rules it out, knowing your status is the first step toward peace of mind and long-term health.

Ready to Take the Next Step?

If you've been advised to have a prostate biopsy or want a second opinion on your PSA levels, Dr. Samadi can help. Schedule a consultation today to learn more about your options and receive the expert guidance you deserve.